Once-daily Toujeo® delivers blood sugar levels that stay in the ADA target zone (80-130 mg/dL) beyond all day and night

If your doctor is suggesting a long-acting insulin, ask about once-daily Toujeo®. You and your doctor may find Toujeo® helps you put your blood sugar back on track.

Toujeo® should be taken once a day at the same time each day

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Insulin, Glucose and You

Insulin and glucose

When you hear the word insulin, you may think of a drug taken by people who have diabetes.

While this is true, what you may not know is that insulin is one of the many hormones created in the human body.

Insulin is important to the body. It allows blood sugar (or glucose) to get into cells to provide them with energy.

When you eat, your body breaks down food into glucose in your small intestine.

This is your body’s source of energy for everything it does, from working and thinking to exercising and healing.

Glucose travels through your bloodstream, looking for individual cells that need energy.

For glucose to get into the cells, it requires insulin.

Insulin is the key that unlocks cells for glucose to enter and deliver energy.

When insulin arrives, it signals the cells to activate glucose transporters.

These transporters pull glucose through cell walls.

When glucose moves into the cell, it delivers energy.

Insulin deficiency

Insulin is normally produced in the pancreas by specialized cells called beta cells.

When glucose enters your bloodstream, the pancreas matches it with the right amount of insulin to move glucose into your cells.

In people with diabetes, this process doesn't work as it should. In type 1 diabetes, scientists believe the body's immune system mistakenly attacks and destroys beta cells in the pancreas. A person with type 1 diabetes loses the ability to produce insulin.

In type 2 diabetes, the pancreas is not producing enough insulin to meet the body's needs. Over time, the amount of insulin typically becomes less and less.

Insulin resistance

In some type 2 diabetes patients, cells build up a resistance to insulin. Even though there may be insulin in the bloodstream, it is not enough to unlock cells to allow glucose to enter.

As a result, it takes more insulin to find the right key to unlock the cell for glucose. This makes it more difficult for cells to get the energy they need.

The effects of diabetes

When glucose can’t get into the cells—either because there isn’t enough insulin or because the body is resisting it—glucose begins to build up in the bloodstream.

As a result, all that energy is wasted. It does not get to cells where it is needed. Without glucose in your cells, they lack the energy they require to keep your body working.

What is Toujeo® (insulin glargine injection) 300 Units/mL?

Prescription Toujeo® is a long-acting insulin used to control blood sugar in adults with diabetes mellitus.

  • Toujeo® contains 3 times as much insulin in 1 mL as standard insulin (100 Units/mL)
  • Toujeo® is not for use to treat diabetic ketoacidosis
  • Toujeo® should not be used in children
Important Safety Information for Toujeo® (insulin glargine injection) 300 Units/mL

Do not take Toujeo® if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo®.

Do NOT reuse needles or share insulin pens even if the needle has been changed.

Before starting Toujeo®, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant or if you are breastfeeding or planning to breastfeed.

Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Toujeo®. Your treatment with TZDs and Toujeo® may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms, including:

  • Shortness of breath
  • Sudden weight gain
  • Swelling of your ankles or feet

Tell your doctor about all the medications you take, including OTC medicines, vitamins, supplements, and herbal supplements.

Toujeo® should be taken at the same time once a day. Test your blood sugar levels daily while using insulin, including Toujeo®. Do not change your dose or type of insulin without talking to your doctor. Verify that you have the correct insulin before each injection. Do NOT use a syringe to remove Toujeo® from your Solostar® pen. Your dose for Toujeo® may be different from other insulins you have taken. Any change of insulin should be made cautiously and only under medical supervision.

Do NOT dilute or mix Toujeo® with any other insulin or solution. It will not work as intended and you may lose blood sugar control, which could be serious. Use Toujeo® only if the solution is clear and colorless with no particles visible.

While using Toujeo®, do not drive or operate heavy machinery until you know how Toujeo® affects you. Don’t drink alcohol or use other medicines that contain alcohol.

The most common side effect of any insulin, including Toujeo®, is low blood sugar (hypoglycemia), which may be serious and life-threatening. Severe hypoglycemia may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision.

Toujeo® may cause severe allergic reactions that can lead to death. Get medical help right away if you have:

  • A rash over your whole body
  • Shortness of breath
  • Swelling of your face, tongue, or throat
  • Extreme drowsiness, dizziness, or confusion
  • Trouble breathing
  • Fast heartbeat
  • Sweating

Toujeo® may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.

Toujeo® SoloStar® is a disposable prefilled insulin pen. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with the pen.

Why insulin is important

When we eat, most of the food is broken down into its basic components. One of them is glucose (sugar), which runs into our bloodstream.

We need insulin to turn that blood sugar into energy that our cells can use.

For many people, just the right amount of insulin is released from the pancreas to help the body use or store the sugar it gets from food.

What is type 2 diabetes?

For people with type 2 diabetes, the pancreas does not produce enough insulin or the body can’t properly use the insulin it produces to keep their blood sugar controlled.

What is type 1 diabetes?

For people with type 1 diabetes, the body does not produce insulin at all. Type 1 diabetes is usually diagnosed in children and young adults and requires insulin therapy and other treatments to manage their condition.

How once-daily Toujeo® may help

Once-daily Toujeo® is a long-acting insulin that is approved for adults with type 1 and type 2 diabetes who have taken insulin and for those who haven’t.

Toujeo® works like your body's insulin, delivering stable blood sugar levels in the ADA target zone (80-130 mg/dL) beyond all day and night

Results from this controlled study of 30 patients may not apply in everyday use

Remember your blood sugar levels may vary depending on your diet, physical activity, medicines, and other factors.

Stable blood sugar levels around the clock

  • Proven significant A1C reduction
  • In studies, patients on Toujeo® stopped taking one of their oral pills and still showed significantly lower A1C
    • Patients were required to stop taking sulfonylureas (a kind of oral diabetes medicine).
  • Taking Toujeo® at the same time each day can help improve your blood sugar control
  • Work with your doctor to pick a time that fits your schedule and take Toujeo® at that time each day

Not all long-acting insulins are the same. Ask your doctor about stable blood sugar levels with steady-release Toujeo®. Learn how Toujeo® works.

ADA - American Diabetes Association

Toujeo (insulin glargine injection) 300 Units/mL COACH