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How Insulin Works | Toujeo® (insulin glargine injection) 300 Units/mL

Remember, insulin is one of the hormones your body makes naturally. If your doctor is suggesting an insulin for you, it may not be your fault. Diabetes changes. A long-acting insulin like Toujeo® can be a step toward better blood sugar control.

Is an insulin like Toujeo something you really need?
Learn more
about why you may need one.


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Insulin, Glucose and You

When you hear the word insulin, you may think of a drug taken by people who have diabetes.

While this is true, what you may not know is that insulin is one of the many hormones created in the human body.

Insulin is important to the body. It allows blood sugar (or glucose) to get into cells to provide them with energy.

When you eat, your body breaks down food into glucose in your small intestine.

This is your body’s source of energy for everything it does, from working and thinking to exercising and healing.

Glucose travels through your bloodstream, looking for individual cells that need energy.

For glucose to get into the cells, it requires insulin.

Insulin is the key that unlocks cells for glucose to enter and deliver energy.

When insulin arrives, it signals the cells to activate glucose transporters.

These transporters pull glucose through cell walls.

When glucose moves into the cell, it delivers energy.

Insulin deficiency

Insulin is normally produced in the pancreas by specialized cells called beta cells.

When glucose enters your bloodstream, the pancreas matches it with the right amount of insulin to move glucose into your cells.

In people with diabetes, this process doesn't work as it should. In type 1 diabetes, scientists believe the body's immune system mistakenly attacks and destroys beta cells in the pancreas. A person with type 1 diabetes loses the ability to produce insulin.

In type 2 diabetes, the pancreas is not producing enough insulin to meet the body's needs. Over time, the amount of insulin typically becomes less and less.

Insulin resistance

In some type 2 diabetes patients, cells build up a resistance to insulin. Even though there may be insulin in the bloodstream, it is not enough to unlock cells to allow glucose to enter.

As a result, it takes more insulin to find the right key to unlock the cell for glucose. This makes it more difficult for cells to get the energy they need.

The effects of diabetes

When glucose can’t get into the cells—either because there isn’t enough insulin or because the body is resisting it—glucose begins to build up in the bloodstream.

As a result, all that energy is wasted. It does not get to cells where it is needed. Without glucose in your cells, they lack the energy they require to keep your body working.

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About once-daily Toujeo: gradual release

Toujeo is a once-daily, long-acting insulin that works like your body's natural insulin. The gradual release gives you no pronounced peak or wear-off between doses.

Meet A1C reduction and blood sugar control

Proven significant
A1C reduction




Stable blood sugar levels

It can help keep blood sugar levels within the ADA target zone all day and night and beyond.

Results from this controlled study of 30 patients may not apply in everyday use.

Toujeo should be taken once a day at the same time each day.

*American Diabetes Association

Lowest volume.
It’s time to think small

A unit of Toujeo has the smallest injection volume compared to a unit of any other long-acting insulin. And the Toujeo SoloStar® pen uses a small, thin needle.

The Toujeo SoloStar pen comes with
real differences

Compared to the #1 prescribed long-acting insulin:

  • Your injection time is cut in half
  • You need to apply less pressure*

*Study performed in a laboratory environment.
Doses were not delivered into tissue.

Unsure about injections? You're not alone

Hear how one Toujeo patient found a way to overcome injection fears.

Considering Toujeo?
Consider this

People give the Toujeo
SoloStar pen

two thumbs up

At the end of a 4-week study, 95% of type 2 first-time insulin users rated the Toujeo SoloStar pen as easy to use.

All patients in the study were trained how to use the pen by their healthcare providers. It is important to ask your healthcare provider how to use the pen before using it.

One more thing

In studies, patients on Toujeo were required to stop taking one of their oral medications (sulfonylureas).

  • Toujeo showed significant A1C reductions
  • Do not change your medications without consulting with your doctor

Toujeo has a small, thin needle.

Want to know even more about Toujeo?

You’re one click away from learning more about the long-acting insulin in the Toujeo SoloStar pen, facts about the Toujeo copay program, and more.

Is it time to
consider Toujeo?

“I’m ready to talk to my doctor and learn about my options.”

― Douglas is a diabetes patient

Download transcript

Douglas: My goals are to be healthy, and to make sure I’m doing my best to manage my diabetes. My diabetes has changed over time, and I wonder if the way I manage it needs to as well. I’m ready to talk to my doctor, and learn about my options.

Vanessa: One option is Toujeo®

VO: (insulin glargine injection) 300 Units/mL.

Vanessa: Toujeo® is a long- acting man-made insulin used to control high blood sugar in adults with diabetes mellitus.

Vanessa: Once-daily Toujeo® is proven to provide blood sugar control, and significant A1C reductions for adults with type 1 and type 2 diabetes.

VO: Do not take Toujeo® if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo®.

Vanessa: Toujeo® works by slowly releasing small amounts of insulin to provide continuous glucose-lowering activity that lasts beyond 24 hours.

VO: Do NOT share your pen(s) with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.

Before starting Toujeo®, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed.

Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Toujeo®. Your treatment with TZDs and Toujeo® may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms, including:

  • Shortness of breath
  • Sudden weight gain
  • Swelling of your ankles or feet

Tell your doctor about all the medications you take, including OTC medicines, vitamins, supplements, and herbal supplements.

Toujeo® should be taken at the same time once a day. Test your blood sugar levels daily while using any insulin. Do not change your dose or type of insulin without talking to your doctor. Verify that you have the correct insulin before each injection. Do NOT use a syringe to remove Toujeo® from your pen. Your dose for Toujeo® may be different from other insulins you have taken. Any change of insulin should be made cautiously and only under medical supervision.

Do NOT dilute or mix Toujeo® with any other insulin or solution. It will not work as intended and you may lose blood sugar control, which could be serious. Use Toujeo® only if the solution is clear and colorless with no particles visible.

While using Toujeo®, do not drive or operate heavy machinery until you know how Toujeo® affects you. Don’t drink alcohol or use other medicines that contain alcohol.

The most common side effect of any insulin, including Toujeo®, is low blood sugar (hypoglycemia), which may be serious and life-threatening. Severe hypoglycemia may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision.

Toujeo® may cause severe allergic reactions that can lead to death. Get medical help right away if you have:

  • A rash over your whole body
  • Shortness of breath
  • Swelling of your face, tongue, or throat
  • Extreme drowsiness, dizziness, or confusion
  • Trouble breathing
  • Fast heartbeat
  • Sweating

Toujeo® may have additional side effects including swelling, weight gain, low potassium, and injection site reactions, which may include change in fat tissue, skin thickening, redness, swelling, and itching.

Toujeo® SoloStar® and Toujeo® Max SoloStar® are disposable prefilled insulin pens. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with the pen.

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Starting Toujeo? There’s a Coach for you

Beginning a newly prescribed treatment can be challenging. COACH is individualized nurse support when you need it. And it's at no cost to you.



If you're new to Toujeo, get your first 3 copays for $0*

then get your next 12 refills for $10 each.

*See full offer terms, including limitations and eligibility restrictions


Get questions
to ask your doctor

Be prepared for your next doctor visit with our downloadable thought starters.


Are you and your doctor ready to make a move to Toujeo?

If eligible, you’ll get a $10* copay on the Toujeo SoloStar® pen, even if it’s not covered by your insurance.