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Transcript for Toujeo_DTC_Branded_patient_video_Bill_2022_ISI_Update

What is Toujeo U-300 (insulin glargine) injection 300 Units/mL?
Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.
• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age

Bill Rodriguez I love living on the coast of California. At night, my wife and I go to sleep listening to the sound of crashing waves. During the day, we work on projects around the house. We also love to garden. We're really stoked about our new lemon tree. I guess that's fitting because I believe when life gives you lemons, you make lemonade.

Bill Rodriguez And believe me, as a person who’s lived with type one diabetes for 45 years, I've had lots of practice. My grandmother and father both had diabetes, so I was disappointed, but not surprised when I was diagnosed. Even though I had watched my dad inject himself, it was still scary being prescribed insulin in high school, and I wasn't very compliant initially.

Bill Rodriguez I eventually learned to handle needles, but I struggled to keep my blood sugar under control. In my early thirties, I finally started on an injectable that worked well for me. But by then the damage was done. I had so many diabetes related complications. Heart and kidney problems, neuropathy in my feet that caused me to lose a couple of toes.

Bill Rodriguez I also had retinopathy in my eye. That was way too many lemons, and I knew something had to change. I realized I had spent years walking out of my doctor's office without asking about medications, without asking how my body worked, without asking anything, really. I failed myself by not learning more about my diabetes and my treatment options. But I began to advocate for myself, and I found a doctor who helped me understand more about my diabetes and really listened to my questions.

Bill Rodriguez He was the one who suggested I try Toujeo. This time I did the research. I looked into Toujeo, and I really liked what I learned. I liked that it’s long lasting, and it was really encouraging to know that so many others were taking it with good results. That's when I said. Let's give it a try. And I'm so glad I did.

Bill Rodriguez Toujeo works well for me. It helps me keep my blood sugar where I need it. And because the Toujeo Max pen holds more insulin and can give a larger dose in one shot, that means fewer injections for me, which I really like. I've learned over the years that if you want a good outcome, you have to put the work in. The diet…

Bill Rodriguez …the exercise, talking with my doctor, that's on me. But the right treatment is key too and I'm really glad I have Toujeo for that. I really shudder to think where my life would be if I hadn't found the right doctor and the right treatment. You know, my grandson and daughter came to live with us when I was still struggling to manage my diabetes.

Bill Rodriguez At that time, I wondered how I would run and play catch and do all those things I dreamed of. But we do. We go to the beach. I take him skateboarding. He's my best companion. It took me a while to figure out what to do when life gave me lemons. But I'm so glad I never gave up.

Important Safety Information for Toujeo U-300 (insulin glargine) injection

Do not use Toujeo if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo.

Do not share your pen(s) with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.

Before starting Toujeo, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed.

Change (rotate) your injection sites within the area you chose with each dose to reduce your risk of getting pitted or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites. Do not use the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred, or damaged.

Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Toujeo. Your treatment with TZDs and Toujeo may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms including:
• Shortness of breath
• Sudden weight gain
• Swelling of your ankles or feet

Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, and herbal supplements.

Toujeo should be taken at the same time once a day. Test your blood sugar levels daily while using any insulin. Do not change your dose or type of insulin without talking to your doctor. Verify you have the correct insulin before each injection. Do NOT use a syringe to remove Toujeo from your pen. Your dose for Toujeo may be different from other insulins you have taken. Any change of insulin should be made cautiously and only under medical supervision.

Do NOT dilute or mix Toujeo with any other insulin or solution. It will not work as intended and you may lose blood sugar control, which could be serious. Use Toujeo only if the solution is clear and colorless with no particles visible.

While using Toujeo, do not drive or operate heavy machinery until you know how Toujeo affects you. Don’t drink alcohol or use other medicines that contain alcohol.

The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening. Severe hypoglycemia may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision. The long-acting effect of Toujeo may delay recovery from low blood sugar compared to shorter-acting insulins.

Toujeo may cause severe allergic reactions that can lead to death. Get medical help right away if you have:
• A rash over your whole body
• Shortness of breath
• Swelling of your face, tongue, or throat
• Extreme drowsiness, dizziness, or confusion
• Trouble breathing
• Fast heartbeat
• Sweating

Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.

Toujeo SoloStar and Toujeo Max SoloStar are single-patient-use prefilled insulin pens. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with your Toujeo SoloStar or Toujeo Max SoloStar pen.



©2024 Sanofi. All rights reserved.
MAT-US-2108218-v3.0-10/2022

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If I Knew Then Video Transcript

Bill: You know, I find that humor makes people feel better. As someone who's had type 2 diabetes for almost 20 years. I find it helps me get through some pretty rough spots.

I guess you could say humor comes naturally to me. I remember, as a kid, I thought I could be pretty funny. I did a stand-up act years ago in the late 80s, played Comedy clubs all around the country.

I couldn't help it. I was always writing jokes or finding the humor in things. Comedy was fun. But then I thought it was time to settle down. I work as a project manager now, but I still love to see people smiling and laughing. I dress up like Santa at Christmas time for the kids at the local hospitals. With this beard, I'm pretty convincing. It's fun for the kids, and it's good for me to see them happy.

When I was first diagnosed with diabetes, it definitely changed how I went about my life. For a while, I manage diabetes with medications, my family is very supportive. My wife Tish gives me endless encouragement and support. She has a good sense of humor, too. And she lightens up my day. Then I went through a period where I admit I wasn't doing that whole due diligence thing. Wasn't on top of it.

I didn't eat right, I didn't exercise much. After a long day at my office and commuting I didn't have the energy to work out plus I wasn't testing my blood sugar levels every day but I've never been one to quit. I'm just not that guy. It's like someone flipped a switch. I said to myself, “Bill you got to stop ignoring the obvious. This diabetes thing isn't going to go away. Get with the program, do whatever you got to do to keep it in check.” So, I talked about it with my doctor and told her about how my diabetes management was going, she explained that diabetes can change over time and that the ways you manage it may have to as well. That's when we decided that Toujeo (insulin glargine) injection 300 Units/mL was an option for me.

Voiceover:
From the makers of Lantus® (insulin glargine) injection 100 Units/mL.
Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.
• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age

Bill: Once daily Toujeo provides proven full 24-hour blood sugar control and significant A1C reductions in adults, with type 1 and type 2 diabetes.

Voiceover:
Important Safety Information for Toujeo U-300 (insulin glargine) injection.

Do not use Toujeo if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo.

Bill: I take Toujeo once a day at the same time every day.

Voiceover:
Toujeo works by slowly releasing small amounts of insulin, to provide continuous glucose-lowering activity, that last beyond 24 hours.

Voiceover:
The most common side effect of any insulin including Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening.
Do not share your pen(s) with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.

Bill: Now, I've been eating better. I limit certain foods like pasta, bread, white flour, sugars. I do a lot of salads and sometimes fish, grilled chicken, that sort of thing. I'm also definitely more mindful when I eat out, it was kind of like a breakup in a relationship, even though I still love him, we just aren't that good together anymore. Cooking took on a new light with diabetes. Also, my little dog Bella helps me exercise. My wife and I like to take her to the dog park.

When Bella has worn out, I know my walks done for the day. You just kind of have to look at it as well. Well, life is always full of things you have to do. She might as well deal with them in a positive way. And if you can find some humor in it and laugh at yourself, that's the way to do it. Now I look at food is part of my treatment, a smart way I can help control my blood sugar. The SoloStar pen has become part of my daily life now. It uses a small thin needle, and I don’t have to press hard to get my dose. I also like that I only need to hold the button down for 5 seconds. Now, my numbers are where my doctor and I wanted them, my blood sugar levels are in a range we set. And my last A1C test was in my target range. Changing up, your lifestyle can be stressful but I found change doesn’t have to be a bad thing. Diabetes doesn't have to be a struggle.

If you work at it, you may end up a stronger person for it, I guess, I've learned that even though I love to make people laugh and help people well, I needed to help myself too. My name is Bill and I help manage my type 2 diabetes with Toujeo. Now it's your turn, talk to your doctor, to see if it's time to work toward your diabetes management goals with Toujeo.

Voiceover:
What is Toujeo U-300 (insulin glargine) injection 300 Units/mL?
Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.
• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age

Important Safety Information for Toujeo U-300 (insulin glargine) injection
Do not use Toujeo if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo.

Do not share your pen(s) with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.

Before starting Toujeo, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed.


Change (rotate) your injection sites within the area you chose with each dose
to reduce your risk of getting pitted or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites. Do not use the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred, or damaged.

Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Toujeo. Your treatment with TZDs and Toujeo may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms including:
• Shortness of breath
• Sudden weight gain
• Swelling of your ankles or feet

Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, and herbal supplements.
Toujeo should be taken at the same time once a day. Test your blood sugar levels daily while using any insulin. Do not change your dose or type of insulin without talking to your doctor. Verify you have the correct insulin before each injection. Do NOT use a syringe to remove Toujeo from your pen. Your dose for Toujeo may be different from other insulins you have taken. Any change of insulin should be made cautiously and only under medical supervision.

Do NOT dilute or mix Toujeo with any other insulin or solution. It will not work as intended and you may lose blood sugar control, which could be serious. Use Toujeo only if the solution is clear and colorless with no particles visible. While using Toujeo, do not drive or operate heavy machinery until you know how Toujeo affects you. Don’t drink alcohol or use other medicines that contain alcohol.

The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening. Severe hypoglycemia may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision. The long-acting effect of Toujeo may delay recovery from low blood sugar compared to shorter-acting insulins. Toujeo may cause severe allergic reactions that can lead to death. Get medical help right away if you have:
• A rash over your whole body
• Shortness of breath
• Swelling of your face, tongue, or throat
• Extreme drowsiness, dizziness, or confusion
• Trouble breathing
• Fast heartbeat
• Sweating

Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.

Toujeo SoloStar and Toujeo Max SoloStar are single-patient-use prefilled insulin pens. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with your Toujeo SoloStar or Toujeo Max SoloStar pen.

©2022 sanofi-aventis U.S. LLC. All rights reserved.
MAT-US-2302826-v1.0-04/2023

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Insulin, Glucose, and You Video Transcript

When you hear the word insulin, you may think of a drug taken by people who have diabetes.While this is true, what you may not know is that insulin is one of the many hormones created in the human body.Insulin is important to the body. It allows blood sugar (or glucose) to get into cells to provide them with energy.When you eat, your body breaks down food into glucose in your small intestine.This is your body’s source of energy for everything it does, from working and thinking to exercising and healing.Glucose travels through your bloodstream, looking for individual cells that need energy.For glucose to get into the cells, it requires insulin.Insulin is the key that unlocks cells for glucose to enter and deliver energy.When insulin arrives, it signals the cells to activate glucose transporters.These transporters pull glucose through cell walls.When glucose moves into the cell, it delivers energy.

Insulin deficiency

Insulin is normally produced in the pancreas by specialized cells called beta cells. When glucose enters your bloodstream, the pancreas matches it with the right amount of insulin to move glucose into your cells. In people with diabetes, this process doesn't work as it should. In type 1 diabetes, scientists believe the body's immune system mistakenly attacks and destroys beta cells in the pancreas. A person with type 1 diabetes loses the ability to produce insulin. In type 2 diabetes, the pancreas is not producing enough insulin to meet the body's needs. Over time, the amount of insulin typically becomes less and less.

Insulin resistance

In some type 2 diabetes patients, cells build up a resistance to insulin. Even though there may be insulin in the bloodstream, it is not enough to unlock cells to allow glucose to enter.As a result, it takes more insulin to find the right key to unlock the cell for glucose. This makes it more difficult for cells to get the energy they need.

The effects of diabetes

When glucose can’t get into cells—either because there isn’t enough insulin or because the body is resisting it—glucose begins to build up in the bloodstream.

As a result, all that energy is wasted. It does not get to cells where it is needed. Without glucose in your cells, they lack the energy they require to keep your body working.

Download Transcript Building a Support System

Voiceover: How important is a support system when it comes to managing your diabetes, Amy?

Amy:Having a support system is huge. Because if you feel like you’re out there all by yourself, it’s really difficult to be successful. One thing I’ve learned about myself is my tendency to become the Queen of Denial – and try to forget I have diabetes. To keep her in check, I need to be accountable to somebody. I have a good friend who works in a different office building, and around lunchtime most days, we’ll call each other or text each other and talk about what we’re eating. Sometimes – during the workday – we take a walk and talk to support each other. That helps us both feel successful. A support system can include a spouse, other family members, friends, coworkers, anyone who can help motivate you.

Voiceover:Lakshmi, what role has a support system played in your diabetes management?

Lakshmi: When it comes to managing my own diabetes, a support system has been essential. My support system has changed over time, and that’s ok. My mom and dad were very supportive early on when I was diagnosed, and then there were my friends and later my husband. Over time, you may need to adjust or add to your support system to make sure you have the right balance to support your diabetes goals.

Voiceover:Javier, when it comes to diabetes management, how important is a support system?

Javier: A support system is very important, but it doesn’t have to be made of people you know well. There are lots of support groups and online forums where we can connect with people with diabetes. I’m a support system for people I’ve met there, and they’re a support system for me. Of course, my family is supportive too -they understand why I need to stay away from certain foods, why I need to keep moving, and all those things - but no one understands quite like my friends in the diabetes community.

©2024 Sanofi. All rights reserved.
MAT-US-2310403-v1.0-04/2024

Download Transcript Fear of Starting Insulin

Voiceover: Amy, what was your reaction when your doctor first said you needed to take insulin?

Amy:I was actually the one who asked my doctor about insulin. We discussed it and decided it was the right thing to do. The funny thing is, it took me three days to go the pharmacy to pick up the prescription. And then, when I brought it home, it took me another couple of days to get up the nerve to give myself the first shot! But after I pushed through the fear and gave myself that first injection, it was fine. And six months later, when I went back to my doctor, we saw that my insulin was working for me. It took a little while to get used to the idea of insulin, but the results were worth it.

Voiceover:Javier, how did you react when your doctor said you needed insulin?

Javier:When I got over the initial shock of my diagnosis, I was 100% focused on managing my diabetes. I wasn’t really upset about having to take insulin. It was just part of the deal. They told me at the beginning, I wasn’t going to be taking any pills. I had to inject myself. Once I understood how important insulin was to managing my blood sugar, I knew it was a tool that I couldn’t do without.

©2024 Sanofi. All rights reserved.
MAT-US-2310410-v1.0-04/2024

Download Transcript Change Can be Scary

Voiceover:Amy, what did you do when you were first diagnosed with diabetes?

Amy:Well, if I’m on this website, I must be a perfect patient, right? Not quite! When I was diagnosed with diabetes 26 years ago, I was the Queen of Denial. And for a long time, my crown just kept getting bigger and more bejeweled. My doctor would tell me, “You need to make these changes,” and then I would go home and not do them. Finally, my dad came to me and said, “You know, I’m worried about you.” When I talked seriously with him and other people who cared about me — and who really became my support system — that gave me the push I needed to start getting better at managing my diabetes.

Voiceover:Lakshmi, what did you do when you found out you had diabetes?

Lakshmi:I was a college student when I was diagnosed with type 2 diabetes, and the first thing I did was call my parents. My family has a long history of diabetes, so I was very aware that I was at risk, and had been getting my blood sugar checked annually. Still, getting the diagnosis was scary! I needed the support of my family to understand what my next steps were and how to get control of it. With the help of my family and my doctor, I quickly figured out what steps I needed to take to better live life with diabetes.

Voiceover:Javier, how did you react when you were diagnosed with diabetes?

Javier:Well, I never expected to hear a doctor tell me, “You have diabetes.” My first reaction was just, “Wow.” I was very shocked. But then I started thinking, “You know, I’ve always been a big sports guy.” So my attitude was, “I’ve got to win.” Diabetes was like an opponent to me and when the nutritionist came in to help me, I thought, “Hey, here’s my coach right there!” Thanks to my treatment regimen, eating better, and doing more physical activity, today I’m managing my opponent very well. My doctor really listens. I learned it’s so important to tell her everything so she can make the best decision for me.

©2024 Sanofi. All rights reserved.
MAT-US-2310107-v1.0-04/2024

Download Transcript Change Can be Scary

Voiceover:Amy, what did you do when you were first diagnosed with diabetes?

Amy:Well, if I’m on this website, I must be a perfect patient, right? Not quite! When I was diagnosed with diabetes 26 years ago, I was the Queen of Denial. And for a long time, my crown just kept getting bigger and more bejeweled. My doctor would tell me, “You need to make these changes,” and then I would go home and not do them. Finally, my dad came to me and said, “You know, I’m worried about you.” When I talked seriously with him and other people who cared about me — and who really became my support system — that gave me the push I needed to start getting better at managing my diabetes.

Voiceover:Lakshmi, what did you do when you found out you had diabetes?

Lakshmi:I was a college student when I was diagnosed with type 2 diabetes, and the first thing I did was call my parents. My family has a long history of diabetes, so I was very aware that I was at risk, and had been getting my blood sugar checked annually. Still, getting the diagnosis was scary! I needed the support of my family to understand what my next steps were and how to get control of it. With the help of my family and my doctor, I quickly figured out what steps I needed to take to better live life with diabetes.

Voiceover:Javier, how did you react when you were diagnosed with diabetes?

Javier:Well, I never expected to hear a doctor tell me, “You have diabetes.” My first reaction was just, “Wow.” I was very shocked. But then I started thinking, “You know, I’ve always been a big sports guy.” So my attitude was, “I’ve got to win.” Diabetes was like an opponent to me and when the nutritionist came in to help me, I thought, “Hey, here’s my coach right there!” Thanks to my treatment regimen, eating better, and doing more physical activity, today I’m managing my opponent very well. My doctor really listens. I learned it’s so important to tell her everything so she can make the best decision for me.

©2024 Sanofi. All rights reserved.
MAT-US-2310107-v1.0-04/2024

Download Transcript Getting Active

Voiceover: Many people struggle with exercise. How do you fit it into your life, Amy?

Amy:For me, exercise is the “E word.” I am just not a fan. It actually helps me to think of it as “movement” and not “exercise.” Exercise to me means going to the gym. Movement is doing things like parking farther away from the store or using the restroom that is farthest away so I’ll have to walk more to get there. I try to get up and move around, take steps whenever I can. I have a fair amount of movement that’s built into my workday. That really helps too. It also really helps me to be accountable to someone. Knowing that someone is going to ask me how many steps I’ve taken or if I’ve been as active as I want to be gives me the push I need.

Voiceover:Lakshmi, how do you approach physical activity?

Lakshmi:I make it a goal to be active for 20 minutes a day, but it’s important to talk with your healthcare provider about what your fitness goals should be. You don’t have to go to a gym or have equipment at home to be active. Sometimes I stand in front of the TV and march in place for 20 minutes. If you have a staircase in your home, you can walk up and down the stairs a few times a day. Even gardening or cleaning house. Just incorporating some activity into my daily routine is what keeps me feeling good.

Voiceover:Javier, how do you make physical activity part of your life?

Javier:Well, my motto has always been, “You’re not training for the Olympics. You’re just training your body to be healthier.” I just keep moving and moving around. If I’m watching a game on TV, I don’t sit. I get up and pace around. Even when I have friends over to watch a big game. People used to say, “Wow, you’re all over the place, you must be nervous.” But I explain to them, “No, I live with diabetes, and getting movement is one of the ways I’m able to manage it.”

©2024 Sanofi. All rights reserved.
MAT-US-2310407-v1.0-04/2024

Download Transcript Starting on Toujeo Max (insulin glargine) injection 300 Units/mL

Voiceover:Prescription Toujeo is a long-acting, man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.

• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age

Please see Full Prescribing Information in the link below

Voiceover:Amy, why did you and your doctor think that Toujeo Max was the right for you?

Amy:I started out on another medication, and then a variety of other options, including Toujeo, became available. So, my doctor and I did some research. I was doing OK, but my doctor and I thought Toujeo Max could be a good choice for me. And here’s some Important Safety Information.

Voiceover:The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening. Ask your doctor about the signs and symptoms of hypoglycemia, how to monitor your blood sugar, and what to do if you have a hypoglycemic event.
Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling and itching.
Please listen to the Important Safety Information at the end of this video for more about Toujeo. Additionally, there is a link with Important Safety Information below.

Amy:My doctor and I decided that I would try Toujeo, and it’s worked well for me. Toujeo is a long-acting insulin that lasts all day. It contains three times as much insulin in one milliliter as standard insulin, which is 100 units per milliliter.

Voiceover:Javier, why did you and your doctor think Toujeo Max would be right for you?

Javier:I was taking another medication, then my doctor said, “I think Toujeo Max could be a good choice for you. Why don’t you try it, keep track of your blood sugar, and let me know what you think?” I tried Toujeo and I saw that my blood sugar level was within the range my doctor wanted for me. My results with Toujeo really surprised me. I kept checking my blood sugar, and I didn’t have to inject again for 24 hours. After the third day I called my doctor and said, “Toujeo is the right choice for me.”

Voiceover: What is Toujeo U-300 (insulin glargine) injection 300 Units/mL? Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.

• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age

Important Safety Information for Toujeo-300(insulin glargine) injection

Do not use Toujeo if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo.

Do not share your pen(s) with other people, even if the needle has been changed.You may give other people a serious infection or get a serious infection from them.
Before starting Toujeo, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed.

Change (rotate) your injection sites within the area you chose with each doseto reduce your risk of getting pitted or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites.Do notuse the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred, or damaged.

Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Toujeo. Your treatment with TZDs and Toujeo may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms including:

• Shortness of breath
• Sudden weight gain
• Swelling of your ankles or feet

Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, and herbal supplements.

Toujeo should be taken at the same time once a day. Test your blood sugar levels daily while using any insulin. Do not change your dose or type of insulin without talking to your doctor. Verify you have the correct insulin before each injection.Do NOT use a syringe to remove Toujeo from your pen.Your dose for Toujeo may be different from other insulins you have taken. Any change of insulin should be made cautiously and only under medical supervision.

Do NOT dilute or mix Toujeo with any other insulin or solution.It will not work as intended and you may lose blood sugar control, which could be serious. Use Toujeo only if the solution is clear and colorless with no particles visible. While using Toujeo, do not drive or operate heavy machinery until you know how Toujeo affects you. Don’t drink alcohol or use other medicines that contain alcohol.

The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening.Severe hypoglycemia may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision. The long-acting effect of Toujeo may delay recovery from low blood sugar compared to shorter-acting insulins. Toujeo may cause severe allergic reactions that can lead to death. Get medical help right away if you have:

• A rash over your whole body
• Shortness of breath
• Swelling of your face, tongue, or throat
• Extreme drowsiness, dizziness, or confusion
• Trouble breathing
• Fast heartbeat
• Sweating

Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.

Toujeo SoloStar and Toujeo Max SoloStar are single-patient-use prefilled insulin pens. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with your Toujeo SoloStar or Toujeo Max SoloStar pen.

©2024 Sanofi. All rights reserved.
MAT-US-2310412-v1.0-04/2024

Download Transcript Insulin the Next Step

Voiceover: Amy, what would you tell someone who’s just getting the news that insulin is the next step for them?

Amy:You just learned that you need insulin? I’m here to tell you, “Insulin is not the scary thing that you think it is.” It’s an important hormone that your body needs to break down your food. Whether you were just diagnosed, or your diabetes has changed over time, you are in good company with people like me, and there are lots of tools and resources to help us live well with diabetes, including insulin.

Voiceover:What would you tell someone who just learned that insulin is the next step for them, Javier?

Javier:Maybe you’re feeling a little nervous about the idea of a shot. But that’s the scary part – the IDEA. The needle on insulin pens is not as large as most people think. When people tell me they’re afraid of the size of the needle, I just show them my pen and they see how small and thin it really is.

Voiceover:Lakshmi, what would you say to someone whose doctor just told them they need insulin?

Lakshmi:Don’t get angry at yourself because you need insulin. Remember, diabetes is a progressive disease, meaning it can change over time. And, because of this, the medication we may need can change too. This is a natural progression for so many of us living with diabetes. Don’t think about what you could have done differently to avoid insulin, think of how insulin is one thing you can incorporate going forward that may help you manage your diabetes. It can help to have those types of discussions with your doctor, too. It’s important to take an active role in the management of your diabetes. So, feel confident to advocate for yourself and have a good conversation with your doctor.

©2024 Sanofi. All rights reserved.
MAT-US-2310415-v1.0-04/2024

Download Transcript Insulin the Next Step

Voiceover: Amy, what would you tell someone who’s just getting the news that insulin is the next step for them?

Amy:You just learned that you need insulin? I’m here to tell you, “Insulin is not the scary thing that you think it is.” It’s an important hormone that your body needs to break down your food. Whether you were just diagnosed, or your diabetes has changed over time, you are in good company with people like me, and there are lots of tools and resources to help us live well with diabetes, including insulin.

Voiceover:What would you tell someone who just learned that insulin is the next step for them, Javier?

Javier:Maybe you’re feeling a little nervous about the idea of a shot. But that’s the scary part – the IDEA. The needle on insulin pens is not as large as most people think. When people tell me they’re afraid of the size of the needle, I just show them my pen and they see how small and thin it really is.

Voiceover:Lakshmi, what would you say to someone whose doctor just told them they need insulin?

Lakshmi:Don’t get angry at yourself because you need insulin. Remember, diabetes is a progressive disease, meaning it can change over time. And, because of this, the medication we may need can change too. This is a natural progression for so many of us living with diabetes. Don’t think about what you could have done differently to avoid insulin, think of how insulin is one thing you can incorporate going forward that may help you manage your diabetes. It can help to have those types of discussions with your doctor, too. It’s important to take an active role in the management of your diabetes. So, feel confident to advocate for yourself and have a good conversation with your doctor.

©2024 Sanofi. All rights reserved.
MAT-US-2310415-v1.0-04/2024

Download Transcript Dealing with Food Cravings

Voiceover:How do you handle cravings for foods that you have to limit, Lakshmi?

Lakshmi:I’ve learned over time that sometimes you have to give yourself grace. If you make a choice to eat something you need to limit, don’t be too hard on yourself. You can start over with the next meal, reset, and do better. Now, you can’t do this all the time, but you can say on occasion, “This wasn’t great, but the next choice I make will be better.” I’ve also learned to stop and think about what the consequences of each choice will be before I act on them. That can be a great motivator to make healthier choices.

Voiceover:Amy, what is the key to handling food cravings for you?

Amy: I’ve discovered that I’m not successful if I over-limit. So let’s say I’m having a massive craving for chocolate. Now, I know what different kinds of chocolate do to my blood sugar. So the question is, if I’m in control, am I willing to accept the consequences? If the answer is yes, then I’ll limit the portion size. I get a taste of the chocolate, it curbs the craving, and the consequences are manageable. My glucose meter is a big help in making these choices. If I check my blood sugar and it’s not where I want it to be, then I know I can’t choose that food right now. But I’ll say to myself, “If I make good, healthy choices for dinner and for breakfast tomorrow, maybe I can have my chocolate then.”

©2024 Sanofi. All rights reserved.
MAT-US-2310406-v1.0-04/2024

Download Transcript Taking an Active Role in the Treatment Discussion

Voiceover:Amy, what medication do you take to help manage your diabetes?

Amy:As part of my treatment regimen, I’m on Toujeo Max, officially known as Toujeo Max (insulin glargine) injection 300 units per milliliter.

Voiceover: Prescription Toujeo is a long-acting, man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.

• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age

Please see Full Prescribing Information in the link below

Amy:I only need to take Toujeo once a day, and I can take it at any time, so I take it every night at the same time - this works for me. I also like that Toujeo Max SoloStar contains up to three times more insulin than most standard long-acting insulin pens, so I use fewer pens per year. Here’s some safety information.

Voiceover:The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening. Ask your doctor about the signs and symptoms of hypoglycemia, how to monitor your blood sugar, and what to do if you have a hypoglycemic event.
Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.
Please listen to the Important Safety Information at the end of this video for more about Toujeo. Additionally, there is a link with Important Safety Information below.

Amy:Keep in mind that each person is different and it’s important to talk to your healthcare provider about what treatment options are best for you.

Voiceover:What medication do you take to help manage your diabetes, Javier?

Javier:I’ve been on Toujeo Max, officially known as Toujeo Max (insulin glargine) injection 300 units per milliliter, since 2015. I take it once a day, around 7 pm. I really like how Toujeo is taken only once a day. This is something that can fit into my routine. I also like that because of the high concentration of insulin available in the Toujeo Max SoloStar pen, there is less liquid to inject per injection. Additionally, I’m able to take the pen on the go without worrying about having to refrigerate it – especially with my active lifestyle and making it to all my grandkids’ sporting events. Remember, what works for me may not work for you, so talk to your healthcare provider about what treatment options are best for you.

Voiceover: What is Toujeo U-300 (insulin glargine) injection 300 Units/mL? Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.

• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age

Important Safety Information for Toujeo-300(insulin glargine) injection

Do not use Toujeo if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo.

Do not share your pen(s) with other people, even if the needle has been changed.You may give other people a serious infection or get a serious infection from them.

Before starting Toujeo, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed.

Change (rotate) your injection sites within the area you chose with each doseto reduce your risk of getting pitted or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites. Do not use the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred, or damaged.

Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Toujeo. Your treatment with TZDs and Toujeo may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms including:

• Shortness of breath
• Sudden weight gain
• Swelling of your ankles or feet

Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, and herbal supplements.

Toujeo should be taken at the same time once a day. Test your blood sugar levels daily while using any insulin. Do not change your dose or type of insulin without talking to your doctor. Verify you have the correct insulin before each injection Do NOT use a syringe to remove Toujeo from your pen.Your dose for Toujeo may be different from other insulins you have taken. Any change of insulin should be made cautiously and only under medical supervision.

Do NOT dilute or mix Toujeo with any other insulin or solution.It will not work as intended and you may lose blood sugar control, which could be serious. Use Toujeo only if the solution is clear and colorless with no particles visible.

While using Toujeo, do not drive or operate heavy machinery until you know how Toujeo affects you. Don’t drink alcohol or use other medicines that contain alcohol.
The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening.Severe hypoglycemia may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision. The long-acting effect of Toujeo may delay recovery from low blood sugar compared to shorter-acting insulins.
Toujeo may cause severe allergic reactions that can lead to death. Get medical help right away if you have:

• A rash over your whole body
• Shortness of breath
• Swelling of your face, tongue, or throat
• Extreme drowsiness, dizziness, or confusion
• Trouble breathing
• Fast heartbeat
• Sweating

Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.

Toujeo SoloStar and Toujeo Max SoloStar are single-patient-use prefilled insulin pens. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with your Toujeo SoloStar or Toujeo Max SoloStar pen.

©2024 Sanofi. All rights reserved.
MAT-US-2310411-v1.0-04/2024

Download Transcript Taking an Active Role in the Treatment Discussion

Voiceover:Amy, what medication do you take to help manage your diabetes?

Amy:As part of my treatment regimen, I’m on Toujeo Max, officially known as Toujeo Max (insulin glargine) injection 300 units per milliliter.

Voiceover: Prescription Toujeo is a long-acting, man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.

• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age


Please see Full Prescribing Information in the link below

Amy:I only need to take Toujeo once a day, and I can take it at any time, so I take it every night at the same time - this works for me. I also like that Toujeo Max SoloStar contains up to three times more insulin than most standard long-acting insulin pens, so I use fewer pens per year. Here’s some safety information.

Voiceover:The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening. Ask your doctor about the signs and symptoms of hypoglycemia, how to monitor your blood sugar, and what to do if you have a hypoglycemic event.
Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.
Please listen to the Important Safety Information at the end of this video for more about Toujeo. Additionally, there is a link with Important Safety Information below.

Amy:Keep in mind that each person is different and it’s important to talk to your healthcare provider about what treatment options are best for you.

Voiceover:What medication do you take to help manage your diabetes, Javier?

Javier:I’ve been on Toujeo Max, officially known as Toujeo Max (insulin glargine) injection 300 units per milliliter, since 2015. I take it once a day, around 7 pm. I really like how Toujeo is taken only once a day. This is something that can fit into my routine. I also like that because of the high concentration of insulin available in the Toujeo Max SoloStar pen, there is less liquid to inject per injection. Additionally, I’m able to take the pen on the go without worrying about having to refrigerate it – especially with my active lifestyle and making it to all my grandkids’ sporting events. Remember, what works for me may not work for you, so talk to your healthcare provider about what treatment options are best for you.

Voiceover: What is Toujeo U-300 (insulin glargine) injection 300 Units/mL? Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.

• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age

Important Safety Information for Toujeo-300(insulin glargine) injection

Do not use Toujeo if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo.

Do not share your pen(s) with other people, even if the needle has been changed.You may give other people a serious infection or get a serious infection from them.

Before starting Toujeo, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed.

Change (rotate) your injection sites within the area you chose with each doseto reduce your risk of getting pitted or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites. Do not use the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred, or damaged.

Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Toujeo. Your treatment with TZDs and Toujeo may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms including:

• Shortness of breath
• Sudden weight gain
• Swelling of your ankles or feet

Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, and herbal supplements.
Toujeo should be taken at the same time once a day. Test your blood sugar levels daily while using any insulin. Do not change your dose or type of insulin without talking to your doctor. Verify you have the correct insulin before each injection Do NOT use a syringe to remove Toujeo from your pen.Your dose for Toujeo may be different from other insulins you have taken. Any change of insulin should be made cautiously and only under medical supervision.

Do NOT dilute or mix Toujeo with any other insulin or solution.It will not work as intended and you may lose blood sugar control, which could be serious. Use Toujeo only if the solution is clear and colorless with no particles visible.

While using Toujeo, do not drive or operate heavy machinery until you know how Toujeo affects you. Don’t drink alcohol or use other medicines that contain alcohol.

The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening.Severe hypoglycemia may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision. The long-acting effect of Toujeo may delay recovery from low blood sugar compared to shorter-acting insulins.

Toujeo may cause severe allergic reactions that can lead to death. Get medical help right away if you have:

• A rash over your whole body
• Shortness of breath
• Swelling of your face, tongue, or throat
• Extreme drowsiness, dizziness, or confusion
• Trouble breathing
• Fast heartbeat
• Sweating

Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.
Toujeo SoloStar and Toujeo Max SoloStar are single-patient-use prefilled insulin pens. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with your Toujeo SoloStar or Toujeo Max SoloStar pen.

©2024 Sanofi. All rights reserved.
MAT-US-2310411-v1.0-04/2024

Download Transcript Lifestyle Changes, Talking to Your Doctor and Taking Small Steps

Voiceover:How did you make lifestyle changes to help manage your diabetes?

Amy:For me, the key was taking baby steps. At first, I was so overwhelmed with all the things I had to do that I just didn’t do any of them. The doctor told me, “You have to learn how to take this medication, you have to eat right, exercise, lose weight, and this, that, and the other thing.” And I was like “What just happened?” I had to break it down. I started with checking my blood sugar and taking my medication. That way, I could have some success right away. Then I started adding some of the other things, like walking a little more. The real turning point was when I went back to my doctor and saw how much I had improved. I’m a different person now, because I know that I can do this!

Javier:My nutritionist brought me a lot of reading material to get me started. So I read and read and read, trying to learn everything I could about diabetes management. If I couldn’t find something in what I got from the nutritionist, I’d look it up on the internet. It wasn’t hard to figure out what I needed to do, but I needed to figure out how to make those changes enjoyable. I had to make better food choices, so I chose to eat more of the vegetables I love. I needed to improve my fitness, so I started moving around a lot more during the day. Those were lifestyle changes, for sure, but they were ones that fit my life.

Lakshmi: I was a college student when I was diagnosed. I’d been eating all kinds of junk and not taking care of my health in general, so I knew I had to change my lifestyle. After talking with my doctor, I started becoming more active and making better food choices. I was lucky to have a great example in my mother who also lived with diabetes. I could follow her lead and take her advice. My dad was a doctor, so that helped too. But even with those things in my favor, it was hard trying to make healthy choices. Sometimes it still is, but I know – after living with diabetes for decades now – that it is worth it.

©2024 Sanofi. All rights reserved.
MAT-US-2310402-v1.0-04/2024

Download Transcript Staying on Track at Holiday Gatherings or Social Events

Voiceover:How do you stick to healthy food choices during the holidays, Amy?

Amy:There are a lot of things about the holidays that require advance planning, right? Well, food choices go on that list too. If I know I want to have my daughter’s famous cookies, then I have to back off on some other things. And I’ve learned some tricks to make holiday parties easier. I make sure to bring something I know is a healthy choice for me to eat. When I’m walking around the room, I make sure I always have some of my food on my plate, so the host doesn’t feel like they have to pile more stuff on top of it. When I really want a treat, it’s just a taste. It's taken a long time, but I’ve learned you can be satisfied with just a taste.

Voiceover:Javier, how do you stick to healthy food choices during the holidays?

Javier:Holidays are when it gets harder for me because my mom cooks the special stuff, like tamales. And I love tamales. There’s nothing like my mother’s homemade tamales! I, in fact, also like to contribute to our big family meals by bringing something that everyone can enjoy that’s also a healthy choice for me. I actually found that most people are really excited to see what I show up with.

©2024 Sanofi. All rights reserved.
MAT-US-2310408-v1.0-04/2024

Download Transcript Communicating with Friends and Family

Voiceover:Amy, a support system is great, but what do you do about people who try to tell you how to manage your diabetes or make you feel bad about your lifestyle choices?

Amy:I try to be the voice of reason and remind people that each of us is a unique individual. What’s best for someone else isn’t necessarily the best thing for me. If people start acting like the “food police” and judging what I’m eating, I’ve found that I can respond in a technical way, and they’ll understand that I know what I’m doing. I say, “Well, this is 27 carbohydrates, and I’ve thought about how it will fit into my meal” or “I’m using the healthy plate method and this is the amount of protein I need.” Most people have your best interest in mind, you just need to help educate them. And the more everyone learns about diabetes, the better!

Voiceover:Javier, what do you do when people try to tell you how to manage your diabetes?

Javier:When people tell me I should eat a certain way or try a new approach to managing my diabetes, I let them know that I appreciate it, because really, they mean well. But it’s also a good time for me to ask myself if what they’re saying is valid. Maybe they have read something that could be helpful to me, but I know I need to talk to my doctor that treats my diabetes and educate myself before I change anything. Because at the end of the day my healthcare team and I are the ones who know the most about my diabetes.

©2024 Sanofi. All rights reserved.
MAT-US-2310405-v1.0-04/2024

Download Transcript Feeling Overwhelmed?

Voiceover:Amy, What would you tell someone who’s feeling overwhelmed after receiving a diagnosis of diabetes or a change in their medication?

Amy:I know from my own experience how overwhelming a diagnosis of diabetes can be. Hearing that your diabetes is changing can also be a real shock. After I learned how good it felt to be managing my diabetes well, I became a Certified Diabetes Educator to help others feel the same. Now, when I talk to newly diagnosed patients, I ask them, “What is one thing that you’re willing to do today to make it better?” Let’s do something easy and get a win under our belts. Then we can move on to other goals. If you break down diabetes management into 3 buckets –medication, food, and exercise or movement – you can then look at what steps you can take in each bucket instead of doing everything all at once. And continue to remind yourself that your doctor may need to change your medication or dose in order to get your numbers in range. When you just take those tiny moments and put them together, that’s what’s really going to help you be successful.

Voiceover:Laskhsmi, what would you tell someone who’s feeling overwhelmed after receiving a diabetes diagnosis or a medication change?

Laskhsmi:I would say the first thing is just to take a step back and try to get a better grasp of what diabetes is and how you can manage it. We can monitor our blood sugar and make those lifestyle choices that help us lead a healthier life. I would also assure you that it’s okay to be overwhelmed. A diabetes diagnosis is serious – and we all hear about bad things associated with it – but there are many ways that we can be successful living with it, based on the choices we make. We can also take an active role in our treatment plan, working with our healthcare team to share our research, talk about our treatment goals and really be part of that decision-making process.

Voiceover:Javier, what advice do you have for someone who is overwhelmed after a diabetes diagnosis or medication change?

Javier:If you’re feeling overwhelmed, I encourage you to read and learn all you can about diabetes. When you first get diagnosed, the initial shock is like, “Wow. Diabetes! Why me?” But the more you read and understand diabetes, you can see that you can control it by making healthy food choices, being active, taking your medication as prescribed — these are some of the things that are going to help you stay healthy.

©2024 Sanofi. All rights reserved.
MAT-US-2310404-v1.0-04/2024

Download Transcript Checking in After Starting Toujeo

Voiceover: Prescription Toujeo is a long-acting, man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.

• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age

Please see Full Prescribing Information in the link below

Voiceover:Amy, how are you doing since you started on Toujeo Max?

Amy:Since starting on Toujeo Max and adding some light activity into my day, I have seen my blood sugar levels improve day when I measure them. And, since Toujeo is taken once daily, it is easy for me to create a routine where I take my Toujeo at the same time each day. I know that Toujeo takes longer to start working in the bloodstream, but it lasts all day long. I also know, that Toujeo contains three times as much insulin in one milliliter as standard insulin 100 units per milliliter, so I inject less liquid per injection because of the higher concentration. And here’s some safety information:

Voiceover:The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening. Ask your doctor about the signs and symptoms of hypoglycemia, how to monitor your blood sugar, and what to do if you have a hypoglycemic event.
Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.


Please listen to the Important Safety Information at the end of this video for more about Toujeo. Additionally, there is a link with Important Safety Information below.

Amy:What makes me – and my doctor - really happy is to know that my A1C stays in my target range. Remember, we’re all individuals, and this is just my experience. Toujeo is not for everyone, and individual results may vary.

Voiceover:Javier, how are you doing since you started on Toujeo Max?

Javier:I’m doing well since I started Toujeo Max. I like that it’s long lasting. I only have to inject Toujeo once a day. I also am encouraged to know that so many others take it with good results. Being consistent with my medication, listening to my doctor, adding exercise to my routine and eating healthier helps me keep focused on the good things in life. I have 11 grandkids who play every sport, and I love being there for all their games.

Javier:Voiceover: What is Toujeo U-300 (insulin glargine) injection 300 Units/mL? Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.

• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age

Important Safety Information for Toujeo U-300 (insulin glargine) injection

Do not use Toujeo if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo.

Do not share your pen(s) with other people, even if the needle has been changed.You may give other people a serious infection or get a serious infection from them.

Before starting Toujeo, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed.

Change (rotate) your injection sites within the area you chose with each doseto reduce your risk of getting pitted or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites.Do notuse the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred, or damaged.

Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Toujeo. Your treatment with TZDs and Toujeo may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms including:

• Shortness of breath
• Sudden weight gain
• Swelling of your ankles or feet

Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, and herbal supplements.

Toujeo should be taken at the same time once a day. Test your blood sugar levels daily while using any insulin. Do not change your dose or type of insulin without talking to your doctor. Verify you have the correct insulin before each injection.Do NOT use a syringe to remove Toujeo from your pen.Your dose for Toujeo may be different from other insulins you have taken. Any change of insulin should be made cautiously and only under medical supervision.

Do NOT dilute or mix Toujeo with any other insulin or solution.It will not work as intended and you may lose blood sugar control, which could be serious. Use Toujeo only if the solution is clear and colorless with no particles visible.

While using Toujeo, do not drive or operate heavy machinery until you know how Toujeo affects you. Don’t drink alcohol or use other medicines that contain alcohol.

The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening.Severe hypoglycemia may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision. The long-acting effect of Toujeo may delay recovery from low blood sugar compared to shorter-acting insulins.

Toujeo may cause severe allergic reactions that can lead to death. Get medical help right away if you have:

• A rash over your whole body
• Shortness of breath
• Swelling of your face, tongue, or throat
• Extreme drowsiness, dizziness, or confusion
• Trouble breathing
• Fast heartbeat
• Sweating

Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.

Toujeo SoloStar and Toujeo Max SoloStar are single-patient-use prefilled insulin pens. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with your Toujeo SoloStar or Toujeo Max SoloStar pen.

©2024 Sanofi. All rights reserved.
MAT-US-2310414-v1.0-04/2024

Download Transcript

How to Use the Toujeo^® SoloStar^® Pens Video Transcript

ANNOUNCER: These instructions do not replace the guidance of your doctor or the instructions for use that accompanies the Toujeo^® SoloStar^® (insulin glargine) injection 300 Units/mL or Toujeo^® Max SoloStar^® pens. People who have vision problems should not use the Toujeo SoloStar or Toujeo Max SoloStar pen without help from a person trained to use the respective pens.

MAX AMY: In this diabetes journey we’re on, have you ever wished you could go back in time and tell yourself the things that you know now, but you didn’t know then?

MAX AMY: Thanks to the wonders of modern technology, we can.

Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus. • Toujeo is not for the treatment of diabetic ketoacidosis • It is not known if Toujeo is safe and effective in children under 6 years of age

Do not use Toujeo if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo.
Do not share your pen(s) with other people, even if the needle has been changed.

MAX AMY: Hey look at that, our first SoloStar pen! I remember that.

MAX AMY: It was a really big deal when I came home with my first pen – it feels like it was only yesterday.

PAST AMY: Oh hey, is that one the same as this one?

MAX AMY: Well your pen is the SoloStar. This one is the Max SoloStar. They’re very similar but there’re some really important differences – but I’ll get to those in a second.

MAX AMY: Did your doctor show you how to use it?

PAST AMY: Yeah, she showed me, but now that I’m home I still have some questions.

MAX AMY: Let me help you get the hang of this.

MAX AMY: There are six steps you need to know: Check the pen, attach the needle, test for safety, select the dosage, inject the insulin, and then remove the needle.

PAST AMY [repeating as if memorizing]: OK. Check the pen, attach the needle, test for safety, select the dosage, inject the insulin, and remove the needle.

MAX AMY: That’s it! You’re ahead of the game already! I knew there was a reason why I liked you.

MAX AMY: So before we do anything, we’re going to make sure the pen is at room temperature, that we have the correct pen, and that it’s working properly.

MAX AMY: Did you take the pen out of the refrigerator about an hour ago? 'Cause cold insulin can be painful…

PAST AMY: Really? Who knew?

MAX AMY: You.

PAST AMY: Good point. This one’s been out of the fridge about an hour. 

MAX AMY: Now look at your pen. I mean, really look at it.

MAX AMY: Is that your pen?

PAST AMY: Yeah.

MAX AMY: Great. Take off the pen cap and check the insulin. It’s clear, not cloudy?

PAST AMY: Clear.

MAX AMY: Perfect! If the insulin’s cloudy, don’t use it, just take it back to your pharmacy.

MAX AMY: Is it past the use-by date?

PAST AMY: Nope.

MAX AMY: Great! Now it’s time to attach the needle.

MAX AMY: Remember, you’re going to need a fresh needle every time you use the pen.

MAX AMY: Don’t reuse and never share needles.

PAST AMY: Even with you?

MAX AMY: Yes, even with me.

PAST AMY: What kind of needles can I use?

MAX AMY: These kind.

MAX AMY: Before you attach the needle, sterilize the tip of the pen with an alcohol wipe.

MAX AMY: Then with the needle you’re going to peel off the protective seal and screw the needle onto the pen, until it feels fixed.

MAX AMY: Then you’re going to remove the outer cap and put that somewhere safe. Then remove the inner needle cap and throw it in the trash.

PAST AMY: Keep the outer cap, toss the inner, got it.

MAX AMY: That’s step two done! With me so far?

PAST AMY: I’m with you.

MAX AMY: Yes, you are. So, before we do anything else, we need to make sure the pen’s working properly.

PAST AMY: What could go wrong?

MAX AMY: Well, sometimes the insulin won’t come out, so we usually check for that.

PAST AMY: OK.

MAX AMY: Testing the pen also resets the dosage knob which is also important.

PAST AMY: Great, so how do I do that?

MAX AMY: Turn the dosage dial to 3, then you’re going to hold it straight up and you’re going to press the injection button all the way in.

MAX AMY: If you see insulin coming out of the needle, then the pen is working and you’re good to go.

MAX AMY: However, if you don’t see insulin coming out, repeat that last step again.

MAX AMY: If you have a new pen, you may need to do this up to six times. Just to get that working. If it still doesn’t work, you need to replace the needle.

PAST AMY: Like in step two?

MAX AMY: Precisely. Oh and by the way, if you see bubbles in your insulin, don’t sweat it.

PAST AMY: Aren’t bubbles in injections bad?

MAX AMY: Nope, not here. You’ve been watching too much TV.

MAX AMY: Ready to inject some insulin?

PAST AMY: OK.

MAX AMY: First, we need to select the correct dosage. So we’re going to turn the dosage selector to your dose. 

MAX AMY: Whatever you and your doctor discussed is what you turn the dial to.

PAST AMY: OK, I need 38 units, so I turn the dial to 38, correct?

MAX AMY: Correct.

MAX AMY: Now this is important: If you have the SoloStar pen, the increments on the dial are one click for one unit, but on the Max SoloStar pen, it’s one click for two units.

MAX AMY: So don’t dial your dose by counting the clicks, or you may dial the wrong dose.

MAX AMY: Either way, just turn the dial so your prescribed dose appears in this window. If there’s not enough insulin in the pen for your prescribed dose, you’ll only be able to dial to the amount that’s left in the pen, and then you’ll need to supplement with a new pen.

PAST AMY: How do I know whether I need the SoloStar or the Max SoloStar?

MAX AMY: As your diabetes changes, your dose may change too, so your doctor may recommend you use a Max SoloStar. Like me. 

PAST AMY: That makes total sense.

MAX AMY: OK, we’re in the home stretch.

MAX AMY: Are you ready for your injection?

PAST AMY: Where can I inject?

MAX AMY: You can inject your dose here, here or here.

MAX AMY: Push the needle into your skin, but don’t touch the injection button yet.

MAX AMY: Put your thumb on the button, press all the way in and hold.

MAX AMY: Hold the button in. When you see “0” in the window, then count to five to make sure you get your full dose.

MAX AMY: After counting to five, release the button and remove the needle from your skin.

PAST AMY: OK, that was pretty easy.

PAST AMY: Well, I barely noticed it at all. How do they do that?

MAX AMY: Thin needles.

MAX AMY: We’re almost done. Now we just need to remove the needle and throw it away safely.

PAST AMY: This really is pretty straightforward.

MAX AMY: I know, right?

MAX AMY: To remove the needle, get the outer needle cap we set aside earlier and carefully place it back on the pen. You put that somewhere safe, right?

PAST AMY: Yep.

MAX AMY: OK.

MAX AMY: These things are sharp. Avoid puncturing the cap, 'cause it will go through.

MAX AMY: Grip and squeeze the widest part of the outer needle cap, then turn your pen several times with your other hand to remove the needle.

PAST AMY: But what if it doesn’t come off right away?

MAX AMY: Just keep trying, it’ll come off eventually.

MAX AMY: Once the needle’s been removed, then we dispose of it in a puncture resistant container.

PAST AMY: Can I just leave the needle on and use it again later?

MAX AMY: No, that’s not a great idea for several reasons: It can leak or get clogged if you leave it on, air could get into the insulin, and there’s the possibility of a bacterial infection.

PAST AMY: So, do I need to put the pen back in the refrigerator when I’m done?

MAX AMY: Nope, that’s the great thing about these pens – you’re good for up to eight weeks after your first use without refrigeration.

PAST AMY: Well that’s handy.

MAX AMY: It sure is.

MAX AMY: So, there you go. That’s all six steps of how to use the Toujeo SoloStar and Max SoloStar insulin pens.

MAX AMY: Just to recap, we learned how to check the pen, attach the needle, test for safety, select your dosage, inject the insulin, and then remove the needle.

PAST AMY: Hey, that was really straightforward. I know the doctor explained it to me, but it really helped to have you explain it again.

MAX AMY: No sweat.

PAST AMY: You know, now that I know, it’s pretty simple. If I wasn’t so nervous, I guess I could have taught myself to do it.

MAX AMY: Well, you know, you kinda did.

ANNOUNCER: An unopened Toujeo SoloStar or Toujeo Max SoloStar pen should be stored in the refrigerator with the pen cap on, at a temperature between 36 degrees Fahrenheit and 46 degrees Fahrenheit (2 degrees Celsius and 8 degrees Celsius) in the box it came in.

Do not freeze new pens.

Refrigerate pens until expiration date.

Discard pens after the expiration date.

An opened Toujeo SoloStar or Toujeo Max SoloStar pen should be stored at room temperature below 86 degrees Fahrenheit (30 degrees Celsius).

Do not refrigerate an opened pen.

Keep out of direct heat and light.

Do not store your pen with the needle attached.

Store your pen with the pen cap on.

Keep pens and needles out of the reach of children.

Discard 56 days after first use, even if the pen still contains insulin.

What is Toujeo U-300 (insulin glargine) injection 300 Units/mL?
Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.

• Toujeo is not for the treatment of diabetic ketoacidosis
• It is not known if Toujeo is safe and effective in children under 6 years of age
   

Important Safety Information for Toujeo U-300 (insulin glargine) injection
Do not use Toujeo if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo.

Do not share your pen(s) with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.

Before starting Toujeo, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed.

Change (rotate) your injection sites within the area you chose with each dose to reduce your risk of getting pitted or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites. Do not use the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred, or damaged.

Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Toujeo. Your treatment with TZDs and Toujeo may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms including:

• Shortness of breath
• Sudden weight gain
• Swelling of your ankles or feet
   

Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, and herbal supplements.

Toujeo should be taken at the same time once a day. Test your blood sugar levels daily while using any insulin. Do not change your dose or type of insulin without talking to your doctor. Verify you have the correct insulin before each injection. Do NOT use a syringe to remove Toujeo from your pen. Your dose for Toujeo may be different from other insulins you have taken. Any change of insulin should be made cautiously and only under medical supervision.

Do NOT dilute or mix Toujeo with any other insulin or solution. It will not work as intended and you may lose blood sugar control, which could be serious. Use Toujeo only if the solution is clear and colorless with no particles visible.

While using Toujeo, do not drive or operate heavy machinery until you know how Toujeo affects you. Don’t drink alcohol or use other medicines that contain alcohol.

The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening. Severe hypoglycemia may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision. The long-acting effect of Toujeo may delay recovery from low blood sugar compared to shorter-acting insulins.

Toujeo may cause severe allergic reactions that can lead to death. Get medical help right away if you have:

• A rash over your whole body
• Shortness of breath
• Swelling of your face, tongue, or throat
• Extreme drowsiness, dizziness, or confusion
• Trouble breathing
• Fast heartbeat
• Sweating
   

Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.

Toujeo SoloStar and Toujeo Max SoloStar are single-patient-use prefilled insulin pens. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with your Toujeo SoloStar or Toujeo Max SoloStar pen. 

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MAT-US-2006936-v2.0-11/2022